Skip to main content

Advertisement

SpringerLink
Log in

Vessel maneuvers: Zinc fingers promote angiogenesis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Zinc-finger transcription factors can be engineered to target specific genes. Now this approach is applied successfully to a clinically relevant setting in mice—promotion of angiogenesis. (pages 1427–1432)

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Designer fingers.

Kimberly Homer

References

  1. Rebar, E.J. et al. Induction of angiogenesis in a mouse model using engineered transcription factors. Nature Med. 8, 1427–1432 (2002).

    Article  CAS  Google Scholar 

  2. Beerli, R.R. & Barbas, C.F. III . Engineering polydactyl zinc-finger transcription factors. Nature Biotechnol. 20, 135–141 (2002).

    Article  CAS  Google Scholar 

  3. Pabo, C.O., Peisach, E. & Grant, R.A. Design and selection of novel Cys2His2 zinc finger proteins. Annu. Rev. Biochem. 70, 313–340 (2001).

    Article  CAS  Google Scholar 

  4. Xu, L. et al. A versatile framework for the design of ligand-dependent, transgene-specific transcription factors. Mol. Ther. 3, 262–273 (2001).

    Article  CAS  Google Scholar 

  5. Guan, X. et al. Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc. Natl. Acad. Sci. USA 99, 13296–13301 (2002).

    Article  CAS  Google Scholar 

  6. Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nature Med. 6, 460–463 (2000).

    Article  CAS  Google Scholar 

  7. Beerli, R.R., Dreier, B. & Barbas III, C.F. Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl. Acad. Sci. USA 97, 1495–1500 (2000).

    Article  CAS  Google Scholar 

  8. Pasqualini, R. & Arap, W. Vascular targeting. in Encyclopedia of Cancer, Vol. 4, 2nd edn. (ed. Bertino, J.R.), 501–507 (Academic Press, San Diego-Oxford, 2002).

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. M.D. Anderson Cancer Center, The University of Texas, Houston, Texas, USA

    Renata Pasqualini & Wadih Arap

  2. The Scripps Research Institute, La Jolla, California, USA

    Carlos F. Barbas III

Authors
  1. Renata Pasqualini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carlos F. Barbas III
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wadih Arap
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Renata Pasqualini or Carlos F. Barbas III.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pasqualini, R., Barbas, C. & Arap, W. Vessel maneuvers: Zinc fingers promote angiogenesis. Nat Med 8, 1353–1354 (2002). https://doi.org/10.1038/nm1202-1353

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1202-1353

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation