Reduction in blood levels of low-density lipoprotein cholesterol reduces the risk of coronary heart disease. The identification of a new class of compounds that upregulate the low-density lipoprotein receptor may lead to new therapeutic advances. (pages 1332–1338)
References
Grundy, S.M. Statin trials and goals of cholesterol-lowering therapy. Circulation 97, 1436–1439 (1998).
Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 2486–2497 (2001).
Grand-Perret, T. et al. SCAP ligands are potent new lipid lowering drugs. Nature Med. 7, 1332–1338 (2001).
Brown, M.S. & Goldstein, J.L. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc. Natl. Acad. Sci. USA 96, 11041–11048 (1999).
Edwards, P.A., Tabor, D., Kast, H.R. & Venkateswaran, A. Regulation of gene expression by SREBP and SCAP. Biochim. Biophys. Acta 1529, 103–113 (2000).
Korn, B.S. et al. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). J. Clin. Invest. 102, 2050–2060 (1998).
Sheng, Z., Otani, H., Brown, M.S. & Goldstein, J.L. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 92, 935–938 (1995).
Repa, J.J. et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 14, 2819–2830 (2000).
Izzat, N.N., Deshazer, M.E. & Loose-Mitchell, D.S. New molecular targets for cholesterol-lowering therapy. J. Pharmacol. Exp. Ther. 293, 315–320 (2000).
Bays, H.E. et al. Effectiveness and tolerability of ezetimibe in patients with primary hypercholesterolemia: pooled analysis of two phase II studies. Clin. Ther. 23, 1209–1230 (2001).
Wetterau, J.R. et al. An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. Science 282, 751–754 (1998).
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Rader, D. A new feature on the cholesterol-lowering landscape. Nat Med 7, 1282–1284 (2001). https://doi.org/10.1038/nm1201-1282
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DOI: https://doi.org/10.1038/nm1201-1282
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