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Keep the 'phospho' on MAPK, be happy

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Depression ruins the lives of millions of people, causing dysphoria and anguish. New findings in rodents and human brain shed light on the mechanisms of this disease, uncovering a phosphatase as a new target to treat depressive behaviors (pages 1328–1332).

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Figure 1: The serine-threonine phosphatase MKP-1 is a key control point in the neurobiology of depression.

Marina Corral

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Authors and Affiliations

  1. Schahram Akbarian is in the Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA,

    Schahram Akbarian

  2. Roger J. Davis is in the Program in Molecular Medicine, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Roger J Davis

Authors
  1. Schahram Akbarian
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  2. Roger J Davis
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Correspondence to Schahram Akbarian or Roger J Davis.

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The authors declare no competing financial interests.

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Akbarian, S., Davis, R. Keep the 'phospho' on MAPK, be happy. Nat Med 16, 1187–1188 (2010). https://doi.org/10.1038/nm1110-1187

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