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Graft-versus-host disease: suppression by statins

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Two big challenges of transplantation biology are controlling the reaction of the graft to the host after hematopoietic stem cell transplantation and preventing rejection of donor organs by the host. Raewyn Broady and Megan K. Levings discuss the first challenge, examining studies suggesting that statins might be helpful to control graft-versus-host disease. Kathryn Wood tackles the second challenge in the context of the 'Edmonton protocol', a procedure that can restore the ability to control blood glucose in people with type 1 diabetes—but only in the short term.

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Figure 1: Statins could alter the balance of CD4+ TH cell subsets and reduce GVHD.

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Authors and Affiliations

  1. Raewyn Broady is in the Department of Medicine and Megan K. Levings is in the Department of Surgery, University of British Columbia and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute. 2660 Oak Street, Vancouver, V6H 3Z6 British Columbia, Canada. mlevings@interchange.ubc.ca,

    Raewyn Broady & Megan K Levings

Authors
  1. Raewyn Broady
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  2. Megan K Levings
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Broady, R., Levings, M. Graft-versus-host disease: suppression by statins. Nat Med 14, 1155–1156 (2008). https://doi.org/10.1038/nm1108-1155

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