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Worms tame mast cells

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A protein produced by parasitic roundworms that inhibits the inflammatory response is shown to prevent mast cell activation. The protein could potentially be used for the management of allergies and asthma (pages 1375–1381).

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Figure 1: ES-62, a secreted phosphorylcholine-containing glycoprotein from a parasitic helminth, inhibits FcɛRI-initiated mast cell activation.

Kim Caesar

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Authors and Affiliations

  1. Edward J. Pearce is in the Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Ave., Philadelphia, Pennsylvania 19104, USA. ejpearce@mail.med.upenn.edu,

    Edward J Pearce

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  1. Edward J Pearce
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Pearce, E. Worms tame mast cells. Nat Med 13, 1288–1289 (2007). https://doi.org/10.1038/nm1107-1288

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  • DOI: https://doi.org/10.1038/nm1107-1288

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