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APC and colon cancer: two hits for one

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Two studies suggest how mutations in the APC tumor suppressor gene can contribute to chromosomal aberrations in precancerous cells.

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Figure 1: APC-mediated tetraploidy.

Kim Caesar

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Authors and Affiliations

  1. Stem Cell Program and Division of Hematology/Oncology, Children's Hospital, Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Boston, 02115, Massachusetts, USA

    Craig J Ceol & Leonard I Zon

  2. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital, Boston, 02115, Massachusetts, USA

    David Pellman

  3. Department of Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    David Pellman

Authors
  1. Craig J Ceol
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  2. David Pellman
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  3. Leonard I Zon
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Ceol, C., Pellman, D. & Zon, L. APC and colon cancer: two hits for one. Nat Med 13, 1286–1287 (2007). https://doi.org/10.1038/nm1107-1286

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