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Preventing kidney cell suicide

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Decreased levels of activated protein C allow for kidney cell death in a mouse model of diabetic nephropathy. The findings suggest that targeting the antiapoptotic protein C pathway could counteract kidney damage in individuals with diabetes (pages 1349–1358).

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Figure 1: Activated protein C (APC) modulates mitochondrial apoptosis in diabetic nephropathy.

Kim Caesar

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Authors and Affiliations

  1. Michael Brownlee is Director of the Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, 10461, New York, USA

    Michael Brownlee

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  1. Michael Brownlee
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Brownlee, M. Preventing kidney cell suicide. Nat Med 13, 1284–1285 (2007). https://doi.org/10.1038/nm1107-1284

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