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Blocking HDACs boosts regulatory T cells

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Histone deacetylase inhibitors, which are in clinical use as anticancer agents, also affect the biology of regulatory T cells. These inhibitors may also hold promise as immunomodulatory drugs (pages 1299–1307).

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Figure 1: Histone deacetylase inhibitors (HDACi) promote Treg cell fate in vivo.

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Authors and Affiliations

  1. Pavan Reddy is in the Department of Internal Medicine and Weiping Zou is in the Department of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109, USA reddypr@umich.edu,

    Pavan Reddy & Weiping Zou

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  1. Pavan Reddy
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  2. Weiping Zou
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Reddy, P., Zou, W. Blocking HDACs boosts regulatory T cells. Nat Med 13, 1282–1284 (2007). https://doi.org/10.1038/nm1107-1282

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