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A sweet path toward tolerance in the gut

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Uncovering how the immune system of the mucosa surmounts allergic reactions may open new avenues to treat inflammatory conditions in the gut. New findings in mice now show that a C-type lectin receptor in dendritic cells (DCs) protects against food antigens that cause systemic anaphylaxis—promoting oral tolerance (pages 1128–1133).

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Figure 1: The C-type lectin SIGNR1 amplifies tolerogenic circuits in mucosal immunity.

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Authors and Affiliations

  1. Argentina and the Departamento de Química Biológica, Gabriel A. Rabinovich is at the Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.,

    Gabriel A Rabinovich

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  1. Gabriel A Rabinovich
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Correspondence to Gabriel A Rabinovich.

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Rabinovich, G. A sweet path toward tolerance in the gut. Nat Med 16, 1076–1077 (2010). https://doi.org/10.1038/nm1010-1076

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