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Gateway to the diseased brain

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The blood-brain barrier constitutes a major obstacle to effective treatment of diseases affecting the central nervous system. A new strategy to target specifically the endothelium of diseased brain may allow the development of more effective gene-based therapies (pages 1215–1218).

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Figure 1: Retargeting of AAV vectors to the diseased brain endothelium.

Katie Vicari

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Authors and Affiliations

  1. Federico Mingozzi and Katherine A. High are in the Division of Hematology, the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.,

    Federico Mingozzi & Katherine A High

  2. Katherine A. High is also at the Howard Hughes Medical Institute, Philadelphia, Pennsylvania, USA.,

    Katherine A High

Authors
  1. Federico Mingozzi
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  2. Katherine A High
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Correspondence to Katherine A High.

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Mingozzi, F., High, K. Gateway to the diseased brain. Nat Med 15, 1123–1124 (2009). https://doi.org/10.1038/nm1009-1123

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