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HIF, a missing link between metabolism and cancer

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Mutations in metabolic enzymes lead to changes in stability of HIF, highlighting the connection between metabolism and cancer.

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Figure 1: Increases in metabolic intermediates lead to HIF stabilization.

Katie Ris

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Authors and Affiliations

  1. Renal Section, Hammersmith Hospital, Imperial College London, London, W12 0NN, UK

    Miguel A Esteban & Patrick H Maxwell

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  1. Miguel A Esteban
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  2. Patrick H Maxwell
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Esteban, M., Maxwell, P. HIF, a missing link between metabolism and cancer. Nat Med 11, 1047–1048 (2005). https://doi.org/10.1038/nm1005-1047

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