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From chemical warfare to breast cancer management

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Figure 1: National Defense Research Council project on chemical warfare at the Department of Chemistry, University of Chicago, 1944.
Figure 2: Summit of the Matterhorn, August 18, 1947.
Figure 3
Figure 4: Selective uptake and retention (without chemical change) of tritiated estradiol by reproductive tissues of the immature rat.
Figure 5: Patient with metastatic breast cancer 3, 8 and 18 months after hypophysectomy.
Figure 6: Correlation of estrogen receptor content with response of breast cancer to endocrine ablation in 160 patients with metastatic disease.

References

  1. Kharasch, M.S., Jensen, E.V. & Urry, W.H. Addition of carbon tetrachloride and chloroform to olefins. Science 102, 128–129 (1945).

    Article  CAS  Google Scholar 

  2. Kharasch, M.S., Nudenberg, W., Jensen, E.V., Fischer, P.E. & Mayfield, D.L. Inhibition of polymerization. Laboratory and plant control of popcorn polymer growth. Ind. Eng. Chem. 39, 830–837 (1947).

    Article  CAS  Google Scholar 

  3. Jensen, E.V. High point. Breast Cancer Res. Treat. 9, 77–86 (1987).

    Article  CAS  Google Scholar 

  4. Huggins, C. & Bergenstal, D.M. Inhibition of human mammary and prostatic cancers by adrenalectomy. Cancer Res. 12, 134–141 (1952).

    CAS  PubMed  Google Scholar 

  5. Jensen, E.V. & Jacobson, H.I. In Biological Activities of Steroids in Relation to Cancer (eds. Pincus, G. & Vollmer, E.P.) 161–174 (Academic Press, New York, 1960).

    Book  Google Scholar 

  6. Jensen, E.V. & Jacobson, H.I. Basic guides to the mechanism of estrogen action. Recent Prog. Horm. Res. 18, 387–414 (1962).

    CAS  Google Scholar 

  7. Jensen, E.V. Mechanism of estrogen action in relation to carcinogenesis. Proc. Can. Cancer Conf. 6, 143–165, 1965.

    Google Scholar 

  8. Toft, D. & Gorski, J. A receptor molecule for estrogens: isolation from the rat uterus and preliminary characterization. Proc. Natl. Acad. Sci. USA 55, 1574–1581 (1966).

    Article  CAS  Google Scholar 

  9. Jensen, E.V. et al. A two-step mechanism for the interaction of estradiol with rat uterus. Proc. Natl. Acad. Sci. USA 59, 632–638 (1968).

    Article  CAS  Google Scholar 

  10. Gorski, J., Toft, D., Shyamala, G., Smith, D. & Notides, A. Hormone receptors: studies on the interaction of estrogen with the uterus. Recent Prog. Horm. Res. 24, 45–80 (1968).

    CAS  PubMed  Google Scholar 

  11. Little, M.P. Szendro, P.I. & Junblut, P.W. Hormone-mediated dimerization of microsomal estradiol receptor. Hoppe-Seyler's Z. Physiol. Chem. 354, 1599–1610 (1973).

    Article  CAS  Google Scholar 

  12. Jensen, E.V. & DeSombre, E.R. Estrogen-receptor interaction: estrogenic hormones effect transformation of specific receptor proteins to a biochemically functional form. Science 182, 126–134 (1973).

    Article  CAS  Google Scholar 

  13. Greene, G.L., Closs, L.E., Fleming, H., DeSombre, E.R. & Jensen, E.V. Antibodies to estrogen receptor: immunochemical similarity of estrophilin from various mammalian species. Proc. Natl. Acad. Sci. USA 74, 3681–3685 (1977).

    Article  CAS  Google Scholar 

  14. Greene, G.L., Nolan, C., Engler, J.P. & Jensen, E.V. Monoclonal antibodies to human estrogen receptor. Proc. Natl. Acad. Sci. USA 77, 5115–5119 (1980).

    Article  CAS  Google Scholar 

  15. Luft, R. & Olivecrona, H. Experiences with hypophysectomy in man. J. Neurosurg. 10, 301–316 (1953).

    Article  CAS  Google Scholar 

  16. Jensen, E.V., Block, G.E., Smith, S., Kyser, K. & DeSombre, E.R. Estrogen receptors and breast cancer response to adrenalectomy. Natl. Cancer Inst. Monogr. 32, 55–70 (1971).

    Google Scholar 

  17. Jensen, E.V., Smith, S. & DeSombre, E.R. Hormone dependency in breast cancer. J. Steroid Biochem. 7, 911–917 (1976).

    Article  CAS  Google Scholar 

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Acknowledgements

And so a road that began with the search for more effective agents to eradicate fellow human beings slowly meandered its way to a program for reducing or eliminating human suffering. During this journey, the author has received assistance, enlightenment, support and encouragement from many sources and individuals. I am grateful to the gifted students, fellows, colleagues and, by no means least, technical assistants who are the backbone of continued research effort. I thank my late wife, Mary, who, with patience and fortitude, brightened the earlier part of the journey, as well as my present wife, Peggy, who will be there on October 1 to celebrate the occasion. And I am thrilled to participate in the 2004 Basic Medical Research Award of the Albert Lasker Foundation; may this organization continue its most valuable mission in stimulating medical research.

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  1. Department of Biology, Vontz Center for Molecular Studies, College of Medicine, University of Cincinnati, Cincinnati, 45267-0521, Ohio, USA

    Elwood V Jensen

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Jensen, E. From chemical warfare to breast cancer management. Nat Med 10, 1018–1021 (2004). https://doi.org/10.1038/nm1004-1018

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