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Myelin failure in multiple sclerosis: Breaking the spell of Notch

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In multiple sclerosis, the myelin sheath is heavily damaged. New evidence suggests that inhibitory signals mediated by the Notch pathway suppress remyelination (pages 1115–1121).

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Figure 1: Proposed signaling cascade inhibiting myelination in an MS lesion in the CNS (ref. 2).

Renee Lucas

Figure 2

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  1. Munich and Department of Neuroimmunology, Institute for Clinical Neuroimmunology Ludwig Maximilians University, Max Planck Institute for Neurobiology, Martinsried, Germany

    Reinhard Hohlfeld

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  1. Reinhard Hohlfeld
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Hohlfeld, R. Myelin failure in multiple sclerosis: Breaking the spell of Notch. Nat Med 8, 1075–1076 (2002). https://doi.org/10.1038/nm1002-1075

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