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Microsatellite alterations in plasma DNA of small cell lung cancer patients

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Abstract

Microsatellite instability is an important characteristic of many tumor types1–8 especially those associated with hereditary non–polyposis colorectal carcinoma (HNPCC) syndrome6–8. Microsatellite alterations in 50% of primary small cell lung carcinoma (SCLC) have been found. These alterations were also found in the sputum4. Because neoplastic characteristics such as decreased strand stability9 and ras mutations10–12 have been found in the plasma DNA of cancer patients, we looked for microsatellite alterations in the plasma of SCLC patients. A microsatellite alteration was present in 16 out of 21 (76%) SCLC tumors and in 15 out of 21 (71%) plasma samples. In one case, the alteration was present only in the plasma DNA. If confirmed in larger studies, microsatellite analysis of plasma DNA might constitute a new tool for tumor staging, management and, possibly, detection.

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Authors and Affiliations

  1. Laboratory of Plant Biochemistry and Physiology, Faculty of Science, Pavilion des Isotopes, 20 boulevard d'Yvoy, Geneva, 1211, Switzerland

    Xu Qi Chen, Maurice Stroun, Jacqueline Lyautey, Christine Lederrey & Philippe Anker

  2. Respiratory Division, Department of Medicine, University of Geneva, Geneva, 1205, Switzerland

    Jean-Luc Magnenat & Laurent P. Nicod

  3. Department of Pathology, Faculty of Medicine, University of Geneva, Geneva, 1205, Switzerland

    Anne-Marie Kurt

Authors
  1. Xu Qi Chen
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  2. Maurice Stroun
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  3. Jean-Luc Magnenat
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  4. Laurent P. Nicod
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  5. Anne-Marie Kurt
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  6. Jacqueline Lyautey
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  7. Christine Lederrey
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  8. Philippe Anker
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Qi Chen, X., Stroun, M., Magnenat, JL. et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 2, 1033–1035 (1996). https://doi.org/10.1038/nm0996-1033

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  • DOI: https://doi.org/10.1038/nm0996-1033

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