The S6K1 kinase lies downstream of a signaling network crucial for muscle hypertrophy. It now seems that S6K1 also interacts with another kinase—AMPK—to integrate muscle-cell growth with metabolic regulation.
References
Glass, D.J. Int. J. Biochem. Cell Biol. 37, 1974–1984 (2005).
Nader, G.A. Int. J. Biochem. Cell Biol. 37, 1985–1996 (2005).
Bodine, S.C. et al. Nat. Cell Biol. 3, 1014–1019 (2001).
Mieulet, V. et al. Am. J. Physiol. Cell Physiol. 293, C712–C722 (2007).
Kahn, B.B., Alquier, T., Carling, D. & Hardie, D.G. Cell Metab. 1, 15–25 (2005).
Bolster, D.R., Crozier, S.J., Kimball, S.R. & Jefferson, L.S. J. Biol. Chem. 277, 23977–23980 (2002).
Chan, A.Y., Soltys, C.L., Young, M.E., Proud, C.G. & Dyck, J.R. J. Biol. Chem. 279, 32771–32779 (2004).
Inoki, K., Zhu, T. & Guan, K.L. Cell 115, 577–590 (2003).
Aguilar, V. et al. Cell Metab. 5, 476–487 (2007).
Ohanna, M. et al. Nat. Cell Biol. 7, 286–294 (2005).
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Nader, G. Muscle growth learns new tricks from an old dog. Nat Med 13, 1016–1018 (2007). https://doi.org/10.1038/nm0907-1016
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DOI: https://doi.org/10.1038/nm0907-1016
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