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A plague upon the phagocytes

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Plague bacteria are renowned for causing some of the most devastating epidemics in human history. We are now closer to understanding why: the pathogen selectively disarms key cells of the innate immune system, weakening the front-line defenses of the body.

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Figure 1: Plague bacteria selectively target key cells of the innate immune system during infection by injecting Yops (Yersinia outer proteins).

Katie Ris

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Authors and Affiliations

  1. Laboratory of Human Bacterial Pathogenesis,

    Frank R DeLeo & B Joseph Hinnebusch

  2. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, 59840, Montana, USA

    Frank R DeLeo & B Joseph Hinnebusch

Authors
  1. Frank R DeLeo
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  2. B Joseph Hinnebusch
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DeLeo, F., Hinnebusch, B. A plague upon the phagocytes. Nat Med 11, 927–928 (2005). https://doi.org/10.1038/nm0905-927

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