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When good cholesterol goes bad

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High density lipoprotein (HDL) is often called the 'good cholesterol.' Products of an inflammatory enzyme, myeloperoxidase, are now shown to selectively target the main protein in HDL, apolipoprotein A-I. This turns the 'good cholesterol' bad.

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Figure 1: Converting the HDL from anti-inflammatory to proinflammatory.

Michael Pace

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Authors and Affiliations

  1. David Geffen School of Medicine at the University of California, Los Angeles, 10833 Le Conte Avenue, Box 951736, Los Angeles, 90095-1736, California, USA

    Alan M Fogelman

  2. Bruin Pharma,

    Alan M Fogelman

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  1. Alan M Fogelman
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Fogelman, A. When good cholesterol goes bad. Nat Med 10, 902–903 (2004). https://doi.org/10.1038/nm0904-902

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  • DOI: https://doi.org/10.1038/nm0904-902

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