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Cancer immunotherapy: breaking the barriers to harvest the crop

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Successful translation of modern molecular immunology into effective cancer immunotherapy is threatened by regulatory barriers and challenges to the development of novel agents and combinatorial strategies through effective public-private partnerships. For its promise to be fully realized, both the National Cancer Institute and Food and Drug Administration must take active steps to help academic investigators and companies jointly navigate the pathways from laboratory to clinic.

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Figure 1: Multiple points of intervention to engender successful cancer immunotherapy.
Figure 2: Potential pathways by which the NCI and FCA could facilitate the development of combinatorial immunotherapies.

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Authors and Affiliations

  1. Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Drew Pardoll

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    James Allison

Authors
  1. Drew Pardoll
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  2. James Allison
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Pardoll, D., Allison, J. Cancer immunotherapy: breaking the barriers to harvest the crop. Nat Med 10, 887–892 (2004). https://doi.org/10.1038/nm0904-887

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