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Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease

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Abstract

Substitutive therapy using fetal striatal grafts in animal models of Huntington disease (HD) have already demonstrated obvious beneficial effects on motor indices1. Using a new phenotypic model of HD recently designed in primates2,3, we demonstrate here complete and persistent recovery in a frontal-type cognitive task two to five months after intrastriatal allografting. The striatal allografts also reduce the occurence of dystonia, a major abnormal movement associated with HD. These results show the capacity of fetal neurons to provide a renewed substrate for both cognitive and motor systems in the lesioned adult brain. They also support the use of neural transplantation as a potential therapy for HD.

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Author notes

  1. Philippe Hantraye: Correspondence should be addressed to P.H.

Authors and Affiliations

  1. CEA CNRS URA 2210, Service Hospitaller Frédéric Joliot, CEA, DSV, DRM, 4 place du Général Leclerc, 91401, Orsay cedex, France

    Stéphane Palfi, Françoise Condé, Emmanuel Brouillet, Caroline Dautry, Vincent Mittoux, Anne Chibois & Philippe Hantraye

  2. INSERM U-421, IM3, Faculté de Médecine, 8 rue du Général Sarrail, 94010, Créteil cedex, France

    Danielle Riche & Marc Peschanski

Authors
  1. Stéphane Palfi
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  2. Françoise Condé
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  3. Danielle Riche
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  4. Emmanuel Brouillet
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  5. Caroline Dautry
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  6. Vincent Mittoux
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  7. Anne Chibois
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  8. Marc Peschanski
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  9. Philippe Hantraye
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Palfi, S., Condé, F., Riche, D. et al. Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease. Nat Med 4, 963–966 (1998). https://doi.org/10.1038/nm0898-963

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  • DOI: https://doi.org/10.1038/nm0898-963

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