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Alzheimer's therapy: a BACE in the hand?

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References

  1. Atwal, J.K. et al. A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo. Sci. Trans. Med. 3, 84ra43 (2011)

    Article  Google Scholar 

  2. Yu, Y.J. et al. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci. Trans. Med. 3, 84ra44 (2011)

    Article  Google Scholar 

  3. Yamakawa, H. et al. β-secretase inhibitor potency is decreased by aberrant beta-cleavage location of the “Swedish mutant” amyloid precursor protein. J. Biol. Chem. 285, 1634–1642 (2010).

    Article  CAS  Google Scholar 

  4. DeMattos, R.B. et al. Peripheral anti-Aβ antibody alters CNS and plasma clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 98, 8850–8855 (2001).

    Article  CAS  Google Scholar 

  5. Vassar, R. et al. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735–741 (1999).

    Article  CAS  Google Scholar 

  6. De Strooper, B., Vassar, R. & Golde, T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat. Rev. Neurol. 6, 99–107 (2010).

    Article  CAS  Google Scholar 

  7. Eli, Lilly . Lilly halts development of semagacestat for Alzheimer's disease based on preliminary results of phase 3 clinical trials. <http://newsroom.lilly.com/releasedetail.cfm?releaseid=499794> (2010).

  8. Rinne, J.O. et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study. Lancet Neurol. 9, 363–372 (2010).

    Article  CAS  Google Scholar 

  9. Alzheimer Research Forum. Uppsala: Is tau immunotherapy taking off? <http://www.alzforum.org/new/detail.asp?id=2824> (2011).

  10. Kim, S.H. et al. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloidβ42 from isolated intact nerve terminals. J. Neurosci. 30, 3870–3875 (2010).

    Article  CAS  Google Scholar 

  11. Yoshimizu, T. & Chaki, S. Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039. Biochem. Biophys. Res. Commun. 315, 493–496 (2004).

    Article  CAS  Google Scholar 

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Competing interests

S.G. is a grantee from Amicus Pharmaceuticals and a data and safety monitoring board member of Pfizer/Johnson&Johnson Alzheimer Immunotherapy Alliance.

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Alzheimer's therapy: a BACE in the hand?. Nat Med 17, 932–933 (2011). https://doi.org/10.1038/nm0811-932

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