Skip to main content

Advertisement

SpringerLink
Log in

Turning on the angiogenic microswitch

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The angiogenic switch, which leads to the activation of endothelial cell proliferation and the growth of new blood vessels, is a crucial step in tumorigenesis. A study now shows that this process is linked to a microRNA in endothelial cells (909–914). Blocking microRNAs may offer new avenues for antiangiogenesis therapy to treat cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: A miR-132–dependent angiogenic microswitch can be targeted to block cancer progression and angiogenesis.

Katie Vicari

References

  1. Hanahan, D. & Folkman, J. Cell 86, 353–364 (1996).

    Article  CAS  PubMed  Google Scholar 

  2. Thurston, G., Noguera-Troise, I. & Yancopoulos, G.D. Nat. Rev. Cancer 7, 327–331 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Anand, S. et al. Nat. Med. 16, 909–914 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bartel, D.P. Cell 136, 215–233 (2009).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Small, E.M., Frost, R.J. & Olson, E.N. Circulation 121, 1022–1032 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Vo, N. et al. Proc. Natl. Acad. Sci. USA 102, 16426–16431 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Henkemeyer, M., et al. Nature 377, 695–701 (1995).

    Article  CAS  PubMed  Google Scholar 

  8. He, L., He, X., Lowe, S.W. & Hannon, G.J. Nat. Rev. Cancer 7, 819–822 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Ma, L., et al. Nat. Biotechnol. 28, 341–347 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Boon, L.M., Mulliken, J.B. & Vikkula, M. Curr. Opin. Genet. Dev. 15, 265–269 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Lagos, D., et al. Nat. Cell. Biol. 12, 513–519 (2010).

    Article  CAS  PubMed  Google Scholar 

  12. Wang, H.W., et al. Nat. Genet. 36, 687–693 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hanna M. Eilken and Ralf H. Adams are at the Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine and University of Münster, Faculty of Medicine, Münster, Germany.,

    Hanna M Eilken & Ralf H Adams

Authors
  1. Hanna M Eilken
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ralf H Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ralf H Adams.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eilken, H., Adams, R. Turning on the angiogenic microswitch. Nat Med 16, 853–854 (2010). https://doi.org/10.1038/nm0810-853

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0810-853

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation