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Neutrophils release brakes of coagulation

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Blood coagulation protects from microbial infections. A recent study now shows that neutrophils fine tune the procoagulant response to invading pathogens (pages 887–896). Neutrophils degrade an inhibitor of coagulation, locally 'trapping' bacteria in small blood vessels. But they also increase blood clots in large vessels in the absence of infection, which may be relevant for the treatment of thrombosis.

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Figure 1: Degradation of TFPI by neutrophils enhances thrombus formation in large blood vessels.

Katie Vicari

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Authors and Affiliations

  1. Wolfram Ruf is in the Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.,

    Wolfram Ruf

  2. Zaverio M. Ruggeri is in the Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA.,

    Zaverio M Ruggeri

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  1. Wolfram Ruf
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  2. Zaverio M Ruggeri
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Correspondence to Wolfram Ruf.

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The authors declare no competing financial interests.

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Ruf, W., Ruggeri, Z. Neutrophils release brakes of coagulation. Nat Med 16, 851–852 (2010). https://doi.org/10.1038/nm0810-851

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