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T time in the brain

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Inflammation in neural tissue has long been suspected to have a role in stroke. A new study in mouse models of focal cerebral ischemia suggest that a stereotyped sequence of T cell infiltration and activation may underlie the progression of brain injury that can last up to days after stroke onset (pages 946–950).

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Figure 1: The sequence of events after cerebral ischemia may comprise multiple phases.

Katie Vicari

References

  1. Wahlgren, N.G. & Ahmed, N. Cerebrovasc. Dis. 17 Suppl 1, 153–166 (2004).

    Article  CAS  Google Scholar 

  2. Chamorro, A. & Hallenbeck, J. Stroke 37, 291–293 (2006).

    Article  Google Scholar 

  3. Shichita, T. et al. Nat. Med. 15, 946–950 2009.

    Article  CAS  Google Scholar 

  4. Gee, J.M., Kalil, A., Shea, C. & Becker, K.J. Stroke 38 Suppl, 783–788 (2007).

    Article  Google Scholar 

  5. Liesz, A. et al. Nat. Med. 15, 192–199 (2009).

    Article  CAS  Google Scholar 

  6. Meisel, C., Schwab, J.M., Prass, K., Meisel, A. & Dirnagl, U. Nat. Rev. Neurosci. 6, 775–786 (2005).

    Article  CAS  Google Scholar 

  7. Offner, H., Vandenbark, A.A. & Hurn, P.D. Neuroscience 158, 1098–1111 (2009).

    Article  CAS  Google Scholar 

  8. Lo, E.H. Nat. Med. 14, 497–500 (2008).

    Article  CAS  Google Scholar 

  9. Enlimomab Acute Stroke Trial Investigators. Neurology 57, 1428–1434 (2001).

  10. Krams, M. et al.; ASTIN Study Investigators. Stroke 34, 2543–2548 (2003).

    Article  CAS  Google Scholar 

  11. Furuya, K. et al. Stroke 32, 2665–2674 (2001).

    Article  CAS  Google Scholar 

  12. Iwanaga, S. & Kawabata, S. Front. Biosci. 3, D973–D984 (1998).

    Article  CAS  Google Scholar 

  13. Levi, M., van der Poll, T. & Büller, H.R. Circulation 109, 2698–2704 (2004).

    Article  Google Scholar 

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Correspondence to Eng H Lo.

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Lo, E. T time in the brain. Nat Med 15, 844–846 (2009). https://doi.org/10.1038/nm0809-844

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  • DOI: https://doi.org/10.1038/nm0809-844

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