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Peroxiredoxin-2 links Cdk5 to neurodegeneration

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Cyclin-dependent kinase 5, a serine/threonine kinase, contributes to neurodegeneration in Parkinson's disease. This kinase is now shown to phosphorylate peroxiredoxin-2, inactivating it, and thereby sensitizing neurons to the deleterious effects of parkinsonian toxins.

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Figure 1: Cyclin-dependent kinase 5 (Cdk5) downregulates peroxiredoxin-2 (Prx2) activity, leading to an accumulation of reactive oxygen species in the MPTP model of Parkinson's disease.

Katie Ris-Vicari

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Authors and Affiliations

  1. Serge Przedborski is in the Departments of Neurology, Pathology, and Cell Biology and the Center for Motor Neuron Biology and Disease, Columbia University, New York, New York 10032, USA. sp30@columbia.edu,

    Serge Przedborski

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  1. Serge Przedborski
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Przedborski, S. Peroxiredoxin-2 links Cdk5 to neurodegeneration. Nat Med 13, 907–909 (2007). https://doi.org/10.1038/nm0807-907

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