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Calculated resistance in cancer

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The future of cancer treatment lies in targeted therapies. That oft-repeated phrase of the last few years comes with a warning: watch out for drug resistance. A new mathematical model explores how combinations of drugs could keep resistance at bay.

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Figure 1: Mathematical modeling defines four pretreatment variables that affect the probability of drug resistance.

Katie Ris

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Authors and Affiliations

  1. Howard Hughes Medical Institute, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, 90095, California, USA

    Charles L Sawyers

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  1. Charles L Sawyers
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Sawyers, C. Calculated resistance in cancer. Nat Med 11, 824–825 (2005). https://doi.org/10.1038/nm0805-824

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