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Staphylococcal protein A inflames the lungs

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Staphylococcal pneumonia is associated with a huge influx of inflammatory cells into the lungs. A major trigger for this event is now revealed. Protein A, a bacterial surface protein, binds the receptor for TNFα, a prominent activator of the innate immune system (pages 842–848).

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Figure 1: Activation of TNFR1 by staphylococcal protein A initiates a signaling cascade leading to NF-κB activation and subsequently to an inflammatory response, including production of cytokines and chemokines and a heavy infiltration of PMNs from the bloodstream.

Kimberly Caesar

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Authors and Affiliations

  1. Swedish Institute for Infectious Disease Control, Solna, the Microbiology and Tumor Biology Center, and the Centre for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden

    Birgitta Henriques Normark, Staffan Normark & Anna Norrby-Teglund

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  1. Birgitta Henriques Normark
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  2. Staffan Normark
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  3. Anna Norrby-Teglund
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Normark, B., Normark, S. & Norrby-Teglund, A. Staphylococcal protein A inflames the lungs. Nat Med 10, 780–781 (2004). https://doi.org/10.1038/nm0804-780

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