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Sealing the leak, healing the heart

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Stabilization of the cardiac ryanodine receptor may represent a new concept in treating sudden cardiac death in several heart disorders.

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Figure 1: Exercise-induced diastolic calcium leak from the sarcoplasmic reticulum may induce delayed-after depolarizations (DADs) and fatal ventricular tachyarrhythmia in different cardiac disorders.

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine III, University of Heidelberg, Bergheimerstrasse 58, Heidelberg, 69115, Germany

    Patrick Most

  2. Department of Surgery, Duke University Medical Center, Box 2606, Durham, 27710, North Carolina, USA

    Walter J Koch

Authors
  1. Patrick Most
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  2. Walter J Koch
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Most, P., Koch, W. Sealing the leak, healing the heart. Nat Med 9, 993–994 (2003). https://doi.org/10.1038/nm0803-993

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