Skip to main content

Advertisement

Log in

The brain splits obesity and hypertension

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Obesity and high blood pressure are commonly associated. A study in mice now shows that hypothalamic inflammatory pathways may be the link connecting these two disorders and a potential target to uncouple obesity-related hypertension from weight gain (pages 883–887).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Overview of the suggested pathways by which obesity and hypertension are linked.

Mary Lou Quillen

References

  1. Hall, J.E. et al. J. Biol. Chem. 285, 17271–17276 (2010).

    Article  CAS  Google Scholar 

  2. Könner, A.C., Klockener, T. & Bruning, J.C. Physiol. Behav. 97, 632–638 (2009).

    Article  Google Scholar 

  3. Lakoski, S.G. et al. J. Hum. Hypertens. 25, 73–79 (2011).

    Article  CAS  Google Scholar 

  4. Purkayastha, S., Zhang, G. & Cai, D. Nat. Med. 17, 883–887 (2011)

    Article  CAS  Google Scholar 

  5. Zhang, X. et al. Cell 135, 61–73 (2008).

    Article  CAS  Google Scholar 

  6. Ni, X.-P. et al. J. Clin. Invest. 111, 1251–1258 (2003).

    Article  CAS  Google Scholar 

  7. Tallam, L.S. et al. Hypertension 46, 326–332 (2005).

    Article  CAS  Google Scholar 

  8. Humphreys, M.H., Ni, X.-P. & Pearce, D. Eur. J. Pharmacol. 660, 43–52 (2011).

    Article  CAS  Google Scholar 

  9. Mehta, S. & Farmer, J.A. Curr. Atheroscler. Rep. 9, 134–138 (2007).

    Article  CAS  Google Scholar 

  10. Rahmouni, K. Curr. Hypertens. Rev. 6, 104–209 (2010).

    Article  CAS  Google Scholar 

  11. Prior, L.J. et al. Hypertension 55, 862–868 (2010).

    Article  CAS  Google Scholar 

  12. Jang, P.-G. et al. J. Biol. Chem. 285, 9706–9715 (2010).

    Article  CAS  Google Scholar 

  13. Harlan, S.M. et al. Circ. Res. 108, 808–812 (2011).

    Article  CAS  Google Scholar 

  14. Hotamisligil, G.S., Shargill, N.S. & Spiegelman, B.M. Science 259, 87–91 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael H Humphreys.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Humphreys, M. The brain splits obesity and hypertension. Nat Med 17, 782–783 (2011). https://doi.org/10.1038/nm0711-782

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0711-782

  • Springer Nature America, Inc.

This article is cited by

Navigation