In the late 1990s the drug gefitinib became a new tool in treating the most common type of lung cancer, called non–small cell lung cancer. But doctors found that even with continued gefitinib treatment, some patients experienced a cancer relapse within a year. For the past several years, researchers have been working to uncover why these patients lost sensitivity to gefitinib and seeking how to overcome resistance to the drug. Kirsten Dorans reports on the strategies scientists are developing to outpace continually evolving cancer.
References
Druker, B.J. et al. Blood 94 (Suppl.), 368a (1999).
Sawyers, C.L. N. Engl. J. Med. 340, 1330–1340 (1999).
Shah, N.P. et al. Cancer Cell 2, 117–125 (2002).
Talpaz, M. et al. N. Engl. J. Med. 354, 2531–2541 (2006).
Kantarjian, H. et al. N. Engl. J. Med. 354, 2542–2551 (2006).
Arteaga, C.L. Exp. Cell Res. 284, 122–130 (2003).
Pao, W. et al. Proc. Natl. Acad. Sci. USA 101, 13306–13311 (2004).
Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Paez, J.G. et al. Science 304, 1497–1500 (2004).
Pao, W. et al. PLoS Med. 2, e17 (2005).
Kobayashi, S. et al. N. Engl. J. Med. 352, 786–792 (2005).
Pao, W. et al. Proc. Natl. Acad. Sci. USA 2, e73 (2005).
Costa, D.B. et al. PLoS Med. 4, 1669–1679 (2007).
Balak, M.N. et al. Clin. Cancer Res. 12, 6494–6501 (2006).
Bean, J. et al. Clin. Cancer Res. 14, 7519–7525 (2008).
Bell, D.W. et al. Nat. Genet. 12, 1315–1316 (2005).
Yun, C.H. et al. Proc. Natl. Acad. Sci. USA 105, 2070–2075 (2008).
Engelman, J.A. et al. Science 316, 1039–1043 (2007).
Bean, J. et al. Proc. Natl. Acad. Sci. USA 104, 20932–20937 (2007).
Carter, T.A. et al. Proc. Natl. Acad. Sci. USA 102, 11011–11016 (2005).
Maheswaran, S. et al. N. Engl. J. Med. 359, 366–377 (2008).
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Dorans, K. Outpacing Cancer. Nat Med 15, 718–722 (2009). https://doi.org/10.1038/nm0709-718
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DOI: https://doi.org/10.1038/nm0709-718
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