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Chipping away at gallstones

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Gallstone disease occurs more frequently in subjects with the metabolic syndrome and type 2 diabetes. Findings in a mouse model suggest that the forkhead transcription factor FoxO1 lies behind this association (pages 778–782).

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Figure 1: Bile formation by hepatocytes.

Katie Ris-Vicari

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Authors and Affiliations

  1. Folkert Kuipers is at the Departments of Pediatrics and Laboratory Medicine, Center for Liver Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands,

    Folkert Kuipers

  2. Albert K. Groen is at the Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. f.kuipers@med.umcg.nl or a.k.groen@uva.amc.nl,

    Albert K Groen

Authors
  1. Folkert Kuipers
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  2. Albert K Groen
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Kuipers, F., Groen, A. Chipping away at gallstones. Nat Med 14, 715–716 (2008). https://doi.org/10.1038/nm0708-715

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