Aβ generation requires γ-secretase activity. Inhibition of γ-secretase may now be easier due to the recent identification of the four proteins that make up the γ-secretase complex.
This is a preview of subscription content, log in via an institution to check access.
Kim Caesar
References
Edbauer, D. et al. Nat. Cell Biol. 5, 486–488 (2003).
Scheuner, D. et al. Nat. Med. 2, 864–870 (1996)
De Strooper, B. et al. Nature 391, 387–390 (1998).
Wolfe, M.S. et al. Nature 398, 513–517 (1999).
Li, Y.M. et al. Nature 405, 689–694 (2000).
Yu, G. et al. Nature 407, 48–54 (2000).
Chung, H.M. et al. Nat. Cell Biol. 3, 1129–1132 (2001).
De Strooper, B. et al. Nature 398, 518–522 (1999).
Francis, R. et al. Dev. Cell 3, 85–97 (2002).
Goutte, C. et al. Proc. Natl. Acad. Sci. USA 99, 775–779 (2002).
Takasugi, N. et al. Nature 422, 438–441 (2003).
Dermaut, B. et al. Trends Genet. 21, 664–672 (2005).
Tanemura, K. et al. J. Biol. Chem. 281, 5037–5041 (2006).
Doglio, L.E. et al. Neuron 50, 359–375 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Takashima, A., Shimojo, M. & Wolozin, B. The players on the γ-secretase team. Nat Med 12, 766–767 (2006). https://doi.org/10.1038/nm0706-766
Issue Date:
DOI: https://doi.org/10.1038/nm0706-766
- Springer Nature America, Inc.