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Cracking the fungal armor

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Fungal cell-wall polymers are potent stimulators of immune responses. New findings reveal that fungi shield inflammatory cell-wall polysaccharides from immune recognition, a process that is disrupted by an antifungal compound.

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Figure 1: C. albicans β-glucan is concealed beneath a mannan layer within the cell wall.

Kim Caesar

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Authors and Affiliations

  1. Infectious Diseases Service, Memorial Sloan-Kettering Cancer Center, and the Immunology Program, Sloan-Kettering Institute, New York, 10021, New York, USA

    Tobias M Hohl & Eric G Pamer

Authors
  1. Tobias M Hohl
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  2. Eric G Pamer
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Hohl, T., Pamer, E. Cracking the fungal armor. Nat Med 12, 730–732 (2006). https://doi.org/10.1038/nm0706-730

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