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Sizing up miRNAs as cancer genes

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Findings over the last year or so have built the case that microRNAs might contribute to cancer. Three studies now definitively show this to be the case and also suggest that these small RNAs could be used to categorize tumors.

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Figure 1: A model of miRNA involvement in cancer by modulation of expression of tumor suppressor genes and oncogenes.

Katie Ris

References

  1. He, L. et al. Nature 435, 828–833 (2005).

    Article  CAS  Google Scholar 

  2. O'Donnell K.A. et al. Nature 435, 839–843 (2005).

    Article  CAS  Google Scholar 

  3. Lu, J. et al. Nature 435, 834–838 (2005).

    Article  CAS  Google Scholar 

  4. Bartel, D.P. Cell 116, 281–297 (2004).

    Article  CAS  Google Scholar 

  5. He, L. et al. Nat. Rev. Genet. 5, 522–531 (2004).

    Article  CAS  Google Scholar 

  6. Ambros, V. Nature 431, 350–355 (2004).

    Article  CAS  Google Scholar 

  7. Lee, R.C. et al. Cell 75, 843–854 (1993).

    Article  CAS  Google Scholar 

  8. Reinhart, B.J. et al. Nature 403, 901–906 (2000).

    Article  CAS  Google Scholar 

  9. Berezikov, E. et al. Cell 120, 21–24 (2005).

    Article  CAS  Google Scholar 

  10. Lewis, B.P. et al. Cell 120, 15–20 (2005).

    Article  CAS  Google Scholar 

  11. Krek, A. et al. Nat. Genet. 37, 495–500 (2005).

    Article  CAS  Google Scholar 

  12. Calin, G.A. et al. Proc. Natl. Acad. Sci. USA 99, 15524–15529 (2002).

    Article  CAS  Google Scholar 

  13. Michael, M.Z. et al. Mol. Cancer Res. 1, 882–891 (2003).

    CAS  PubMed  Google Scholar 

  14. Johnson, S.M. et al. Cell 120, 635–647 (2005).

    Article  CAS  Google Scholar 

  15. Dimova, D.K. et al. Oncogene 24, 2810–2826 (2005).

    Article  CAS  Google Scholar 

  16. Meltzer, P.S. Nature 435, 745–746 (2005).

    Article  CAS  Google Scholar 

  17. Weinberg, R.A. Cell 85, 457–459 (1996).

    Article  CAS  Google Scholar 

  18. Weinholds, E. et al. Science published online 26 May 2005 (10.1126/science.1114519).

  19. Iwai, N. et al. Biochem. Biophys. Res. Commun. 331, 1439–1444 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Oncology, Cancer Genomics Program, University of Cambridge and Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, CB2 2XZ, UK

    Carlos Caldas & James D Brenton

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  1. Carlos Caldas
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  2. James D Brenton
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Caldas, C., Brenton, J. Sizing up miRNAs as cancer genes. Nat Med 11, 712–714 (2005). https://doi.org/10.1038/nm0705-712

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