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Calcineurin—the missing link in cardiac hypertrophy

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Transgenic mice that overexpress calcineurin develop cardiac hypertrophy, which can be prevented by treatment with immunosuppressive drugs that inhibit calcineurin.

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References

  1. Molkentin, J.D. et al. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93, 215–228 (1998).

    Article  CAS  Google Scholar 

  2. Sadoshima, J. & Izumo, S. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59, 551–571 (1997).

    Article  CAS  Google Scholar 

  3. Gruver, C.L., DeMayo, F., Goldstein, M.A. & Means, A.R. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice. Endocrinology 133, 376–388 (1993).

    Article  CAS  Google Scholar 

  4. Morgan, J.P., Erny, R.E., Allen, P.D., Grossman, W. & Gwathmey, J.K. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81, 21–32 (1990).

    Google Scholar 

  5. Takahashi, T. et al. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J. Clin. Invest. 90, 927–935 (1992).

    Article  CAS  Google Scholar 

  6. Herzig, T.C. et al. Angiotensin II type 1α receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc. Natl. Acad. Sci. USA 94, 7543–7548 (1997).

    Article  CAS  Google Scholar 

  7. Rao, A., Luo, C. & Hogan, P.G. Transcription factors of the NF-AT family: Regulation and function. Annu. Rev. Immunol. 15, 707–747 (1997).

    Article  CAS  Google Scholar 

  8. Schreiber, S.L. & Crabtree, G.R. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136–142 (1992).

    Article  CAS  Google Scholar 

  9. Katz, A.M. Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure. N. Engl. J. Med. 322, 100–110 (1990).

    Article  CAS  Google Scholar 

  10. Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. & Healy, J.I. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386, 855–858 (1997).

    Article  CAS  Google Scholar 

  11. Mason, J.W. et al. A clinical trial of immunosuppressive therapy for myocarditis. The Myocarditis Treatment Trial Investigators. N. Engl. J. Med. 333, 269–275 (1995).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Cardiovascular Division, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02215, USA

    Seigo Izumo & Hiroki Aoki

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  1. Seigo Izumo
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  2. Hiroki Aoki
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Izumo, S., Aoki, H. Calcineurin—the missing link in cardiac hypertrophy. Nat Med 4, 661–662 (1998). https://doi.org/10.1038/nm0698-661

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