The success of organ transplantation is severely hindered by immune-mediated rejection, but the steps involved in this process remain poorly defined. A new imaging study now reveals the sequence of events and immune cells involved in graft rejection in a mouse model, providing insights into the points at which the immune system could be rationally targeted to prevent transplant rejection (pages 744–749).
References
Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 101, 998–1003 (2004).
Miller, M.J., Safrina, O., Parker, I. & Cahalan, M.D. J. Exp. Med. 200, 847–856 (2004).
Miller, M.J., Wei, S.H., Parker, I. & Cahalan, M.D. Science 296, 1869–1873 (2002).
Miller, M.J., Wei, S.H., Cahalan, M.D. & Parker, I. Proc. Natl. Acad. Sci. USA 100, 2604–2609 (2003).
Garrod, K.R. et al. J. Immunol. 184, 2329–2336 (2010).
Cahalan, M.D. & Parker, I. Annu. Rev. Immunol. 26, 585–626 (2008).
Sen, D., Forrest, L., Kepler, T.B., Parker, I. & Cahalan, M.D. Proc. Natl. Acad. Sci. USA 107, 8334–8339 (2010).
Matheu, M.P. et al. Immunity 29, 602–614 (2008).
Celli, S. et al. Nat. Med. 17, 744–749 (2011).
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Cahalan, M. Imaging transplant rejection: a new view. Nat Med 17, 662–663 (2011). https://doi.org/10.1038/nm0611-662
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DOI: https://doi.org/10.1038/nm0611-662
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