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Microflora in colorectal cancer: a friend to fear

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Activation of Toll-like receptor (TLR) signaling by microbes in the intestine promotes tumor growth in genetically susceptible mice. Inactivation of extracellular signal–regulated kinase (ERK), a molecule downstream of TLR signaling, may offer a route to preventing colorectal cancer (pages 665–670).

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Figure 1: Contribution of bacterial signaling to intestinal tumorigenesis through stabilization of c-myc via TLR-MyD88–mediated activation of ERK.

Kimberly Caesar

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Authors and Affiliations

  1. Masayuki Fukata is in the Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.,

    Masayuki Fukata

  2. Maria T. Abreu is Professor of Medicine and Chief of the Division of Gastroenterology, University of Miami Miller School of Medicine, Miami, Florida, USA.,

    Maria T Abreu

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  1. Masayuki Fukata
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  2. Maria T Abreu
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Correspondence to Maria T Abreu.

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Fukata, M., Abreu, M. Microflora in colorectal cancer: a friend to fear. Nat Med 16, 639–641 (2010). https://doi.org/10.1038/nm0610-639

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