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Selecting the right patient for tumor therapy

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Two clinical studies have identified mutations affecting the EGF receptor in lung cancers from patients who respond robustly to gefitinib, a small-molecule inhibitor of the receptor tyrosine kinase. This work highlights the importance of conducting clinical trials with an eye to delivering molecule-targeted therapeutics to those patients most likely to benefit.

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Figure 1: Selecting for tumor shinkage.

Kimberly Caesar

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Authors and Affiliations

  1. Departments of Medicine and Cancer Biology and Breast Cancer Program, Vanderbilt-Ingram Comprehensive Cancer Center and Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Carlos L Arteaga

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  1. Carlos L Arteaga
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Arteaga, C. Selecting the right patient for tumor therapy. Nat Med 10, 577–578 (2004). https://doi.org/10.1038/nm0604-577

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