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FANCD2: A branch-point in DNA damage response?

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The Fanconi anemia D2 protein is vital for cellular resistance to DNA cross-linking. Now, FANCD2 is shown to also be involved in a second, independent function, the arrest of DNA synthesis after ionizing radiation.

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Figure 1: DNA damage signaling through FANCD2.

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Authors and Affiliations

  1. Department of Molecular and Medical Genetics Oregon Health Science University, Portland, Oregon, USA

    Markus Grompe

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  1. Markus Grompe
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Grompe, M. FANCD2: A branch-point in DNA damage response?. Nat Med 8, 555–556 (2002). https://doi.org/10.1038/nm0602-555

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