A recent study shows that the birth of new nerve cells occurs in the brains of adult monkeys.
References
Gould, E., Tanapat, P., McEwen, B.S., Flügge, G. & Fuchs, E. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc. Natl. Acad. Sci. USA 95, 3168–3171 (1998).
Altman, J. & Das, G.D. Autoradiographic and histologic evidence of postnatal neurogenesis in rats. J. Comp. Neurol. 124, 319–335 (1965).
Cameron, H.A., Woolley, C.S., McEwen, B.S. & Gould, E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neurosci 56, 337–344 (1993).
Kempermann, G., Kuhn, H.G. & Gage, F.H. More hippocampal neurons in adult mice living in an enriched environment. Nature 386, 493–495 (1997).
Kaplan, M.S. & Hinds, J.W. Neurogenesis in the adult rat: electron microscopic analysis of light autoradiographs. Science 197, 1092–1094 (1977).
Palmer, T.D., Ray, J. & Gage, F.H. FGF-2 responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol. Cell. Neurosci. 6, 474–486 (1995).
Fisher, L.J. Neural precursor cells: applications for the study and repair of the central nervous system. Neurobiol. Dis. 4, 1–22 (1997).
Vescovi, A.L., Reynolds, B.A., Fraser, D.D. & Weiss, S. S. bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cells. Neuron 11, 951–966 (1993).
Reynolds, B.A. & Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707–1710 (1992).
Rakic, P. Limits of neurogenesis in primates. Science 227, 1054–1056 (1985).
Rakic, P. DNA synthesis and cell division in the adult primate brain. Ann. N.Y. Acad. Sci. 457, 193–209 (1985).
Kempermann, G., Kuhn, H.G. & Gage, F.H. Experience-induced neurogenesis in the senescent dentate gyrus. J. Neurosci. (in the press).
Gould, E., McEwen, B.S., Tanapat, P., Galea, L.A.M. & Fuchs, E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J. Neurosci. 17, 2492–2498 (1997).
Nowakowski, R.S. & Rakic, P. The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey. J. Comp. Neurol. 196, 129–154 (1981).
Rakic, P. & Nowakowski, R.S. The time of origin of neurons in the hippocampal region of the rhesus monkey. J. Comp. Neurol. 196, 99–128 (1981).
Eckenhoff, M.F. & Rakic, P. Nature and fate of proliferative cells in the hippocampal dentate gyrus during the life span of the rhesus monkey. J. Neurosci. 8, 2729–2747 (1988).
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Kempermann, G., Gage, F. Closer to neurogenesis in adult humans. Nat Med 4, 555–557 (1998). https://doi.org/10.1038/nm0598-555
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DOI: https://doi.org/10.1038/nm0598-555
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