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Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans

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Abstract

Idiopathic voiding disorders affect up to 10–15% of men and women. We describe bladder abnormalities in mice with targeted deletion of the gene for neuronal nitric oxide synthase which model the clinical disorders. The mice possess hypertrophic dilated bladders and dysfunctional urinary outlets which do not relax in response to electrical field stimulation or L-arginine. The mice also display increased urinary frequency.

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Authors and Affiliations

  1. Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Arthur L. Burnett, David C. Calvin, Shelly L. Chamness & Jian-Xiang Liu

  2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Valina L. Dawson & Ted M. Dawson

  3. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Valina L. Dawson, Ted M. Dawson & Solomon H. Snyder

  4. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Solomon H. Snyder

  5. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Solomon H. Snyder

  6. Department of Physiology, and Psychology, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Valina L. Dawson

  7. Department of College of Arts and Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Randy J. Nelson & Sabra L. Klein

Authors
  1. Arthur L. Burnett
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  2. David C. Calvin
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  3. Shelly L. Chamness
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  4. Jian-Xiang Liu
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  5. Randy J. Nelson
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  6. Sabra L. Klein
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  7. Valina L. Dawson
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  8. Ted M. Dawson
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  9. Solomon H. Snyder
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Burnett, A., Calvin, D., Chamness, S. et al. Urinary bladder-urethral sphincter dysfunction in mice with targeted disruption of neuronal nitric oxide synthase models idiopathic voiding disorders in humans. Nat Med 3, 571–574 (1997). https://doi.org/10.1038/nm0597-571

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  • DOI: https://doi.org/10.1038/nm0597-571

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