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The B-side story in insulin resistance

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Although leukocyte activation in fat tissue promotes obesity-related insulin resistance, a role for B cells has been unclear. A new study in obese mice shows that they enter the fat tissue to activate T cell function and boost inflammation, exacerbating the metabolic disease (pages 610–617).

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Figure 1: B cell cooperation with T cells and the release of antibodies mediates the pathogenesis of obesity-related insulin resistance.

Marina Corral

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Authors and Affiliations

  1. Ziad Mallat is in the Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK and at Institut National de la Santé et de la Recherche Médicale, Paris, France.,

    Ziad Mallat

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  1. Ziad Mallat
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Correspondence to Ziad Mallat.

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Mallat, Z. The B-side story in insulin resistance. Nat Med 17, 539–540 (2011). https://doi.org/10.1038/nm0511-539

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