Although leukocyte activation in fat tissue promotes obesity-related insulin resistance, a role for B cells has been unclear. A new study in obese mice shows that they enter the fat tissue to activate T cell function and boost inflammation, exacerbating the metabolic disease (pages 610–617).
References
Lumeng, C.N., Bodzin, J.L. & Saltiel, A.R. J. Clin. Invest. 117, 175–184 (2007).
Nishimura, S. et al. Nat. Med. 15, 914–920 (2009).
Winer, S. et al. Nat. Med. 15, 921–929 (2009).
Feuerer, M. et al. Nat. Med. 15, 930–939 (2009).
Winer, D.A. et al. Nat. Med. 610–617 (2011).
Edwards, J.C. & Cambridge, G. Nat. Rev. Immunol. 6, 394–403 (2006).
Ait-Oufella, H. et al. J. Exp. Med. 207, 1579–1587 (2010).
Weisberg, S.P. et al. J. Clin. Invest. 116, 115–124 (2006).
Hotamisligil, G.S. Nature 444, 860–867 (2006).
Liu, J. et al. Nat. Med. 15, 940–945 (2009).
Baumgarth, N. Nat. Rev. Immunol. 11, 34–46 (2011).
Fillatreau, S., Gray, D. & Anderton, S.M. Nat. Rev. Immunol. 8, 391–397 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Mallat, Z. The B-side story in insulin resistance. Nat Med 17, 539–540 (2011). https://doi.org/10.1038/nm0511-539
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0511-539
- Springer Nature America, Inc.