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Fibrosis under arrest

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Approximately 5% of people that are hospitalized for any reason develop acute kidney failure, which, in some cases, progresses to a chronic condition resulting in fibrosis of the kidney and permanent changes in the organ's function. Two new studies suggest that cell cycle arrest of epithelial cells and epigenetic modifications have key roles in the switch to chronic disease (pages 535–543 and 544–550).

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Figure 1: Epithelial cell cycle arrest in G2/M and epigenetic changes in fibroblasts coordinately promote kidney fibrosis.

Kimberly Caesar

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Authors and Affiliations

  1. Thomas A. Wynn is the chief of the Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.,

    Thomas A Wynn

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  1. Thomas A Wynn
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Correspondence to Thomas A Wynn.

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Wynn, T. Fibrosis under arrest. Nat Med 16, 523–525 (2010). https://doi.org/10.1038/nm0510-523

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