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A new way to regulate the NMJ

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A key regulator of the neuromuscular junction, the transcriptional co-activator PGC-1α, is a potential target for Duchenne muscular dystrophy therapy.

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Figure 1: Model for the transcriptional activation by PGC-1α.

Kim Caesar

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Authors and Affiliations

  1. Departments of Physiology, Kay E Davies is at the MRC Functional Genetics Unit, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK. Kay.davies@dpag.ox.ac.uk,

    Kay E Davies

  2. Tejvir S Khurana is in the Department of Physiology and at the Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Richards Building, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA. tsk@mail.med.upenn.edu,

    Tejvir S Khurana

Authors
  1. Kay E Davies
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  2. Tejvir S Khurana
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Competing interests

K.E.D. is a major shareholder of VASTox plc., a company concerned with the development of treatments for muscular dystrophy.

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Davies, K., Khurana, T. A new way to regulate the NMJ. Nat Med 13, 538–539 (2007). https://doi.org/10.1038/nm0507-538

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