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Finally, mice with CF lung disease

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Increasing sodium absorption by overexpressing the epithelial sodium channel in mouse airways results in mucus accumulation and inflammation, changes that occur in the lungs of individuals with cystic fibrosis. The development of lung disease in these mice should provide insights into a disease that has long been lacking an animal model (pages 487–493).

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Figure 1: Modeling cystic fibrosis.

Kimberly Caesar

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Authors and Affiliations

  1. Departments of Cell Biology and Physiology and of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, 15261, Pennsylvania, USA

    Raymond A Frizzell & Joseph M Pilewski

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  1. Raymond A Frizzell
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  2. Joseph M Pilewski
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Frizzell, R., Pilewski, J. Finally, mice with CF lung disease. Nat Med 10, 452–454 (2004). https://doi.org/10.1038/nm0504-452

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