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Multidrug resistance — a multiplex phenomenon

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Evidence suggests that expression of the MDR1 gene in human tumors is associated with malignancy in a tissue-dependent fashion (pages 447–450).

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References

  1. Gottesman, M.M. & Pastan, I. Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem. 62, 385–427 (1993).

    Article  CAS  Google Scholar 

  2. Chabner, B.A. & Fojo, A. Multidrug resistance: P-glycoprotein and its allies —; the elusive foes. J. Natl. Cancer Inst. 81, 910–913 (1989).

    Article  CAS  Google Scholar 

  3. Bargou, R.C. et al. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nature Med. 4, 447–450 (1997).

    Article  Google Scholar 

  4. Cordon-Cardo, C. et al. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J. Histochem. Cytochem. 38, 1277–1287 (1990).

    Article  CAS  Google Scholar 

  5. van Kalken, C.K. et al. Multidrug resistance gene (P-glycoprotein) expression in the human fetus. Am. J. Pathol. 141, 1063–1072 (1992).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Baldini, N. et al. Nuclear immunolocalization of P-glycoprotein in multidrug resistant cell lines showing similar mechanisms of doxorubicin distribution. Eur. J. Cell Biol. 68, 226–239 (1995).

    CAS  PubMed  Google Scholar 

  7. Valverde, M.A. et al. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 355, 830–833 (1992).

    Article  CAS  Google Scholar 

  8. Abrahams, E.H. et al. The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc. Natl. Acad. Sci. USA 90, 312–316 (1993).

    Article  Google Scholar 

  9. Goldstein, L.J. et al. Expression of a multidrug resistance gene in human cancers. J. Natl. Cancer Inst. 81, 116–124 (1989).

    Article  CAS  Google Scholar 

  10. Biedler, J.L. & Spengler, B.A. Reverse transformation of multidrug-resistant Cells. Cancer Metastasis Rev. 13, 191–207 (1994).

    Article  CAS  Google Scholar 

  11. Bradley, G. & Ling, V., P-glycoprotein, multidrug resistance and tumor progression. Cancer Metastasis Rev. 13, 223–233 (1994).

    Article  CAS  Google Scholar 

  12. Linn, S.C. et al. p53 and P-glycoprotein are often co-expressed and are associated with poor prognosis in breast cancer. Br. J. Cancer 74, 63–68 (1996).

    Article  CAS  Google Scholar 

  13. Chin, K.-V., Ueda, K., Pastan, I. & Gottesman, M.M. Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science 255, 459–462 (1992).

    Article  CAS  Google Scholar 

  14. Kohno, K. et al. Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells. J. Biol. Chem. 269, 20503–20508 (1994).

    CAS  PubMed  Google Scholar 

  15. Goldsmith, M.E., Madden, M.J., Morrow, C.S. & Cowan, K.H. A Y-box consensus sequence is required for basal expression of the human multidrug resistance (MDR1) gene. J. Biol. Chem. 268, 5856–5860 (1993).

    CAS  PubMed  Google Scholar 

  16. Wolffe, A.P. Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteins. BioEssays 16, 245–251 (1994).

    Article  CAS  Google Scholar 

  17. Ladomery, M. & Sommerville, J. A role for Y-box proteins in cell proliferation. BioEssays 17, 9–11 (1995).

    Article  CAS  Google Scholar 

  18. Scotlandi, K. et al. Multidrug resistance and malignancy in human osteosarcoma. Cancer Res. 56, 2434–2439 (1996).

    CAS  PubMed  Google Scholar 

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  1. Laboratorio di Ricerca Oncologica Istituti Ortopedici Rizzoli, 40136, Bologna, Italy

    Nicola Baldini

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  1. Nicola Baldini
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Baldini, N. Multidrug resistance — a multiplex phenomenon. Nat Med 3, 378–380 (1997). https://doi.org/10.1038/nm0497-378

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