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Molecular DIY with hairpins and hammerheads

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Ribozymes can inhibit gene expression in a sequence-specific manner by catalysing cleavage of target messenger RNAs. They can also be used to for DIY (do-it-yourself) surgery on defective RNAs. The potential therapeutic applications of these ribozyme properties were discussed at a recent meeting.

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  1. Pley, H.W., Flaherty, K.M. & Mckay, D.B. Three-dimensional structure of a hammerhead ribozyme. Nature 372, 68–74 (1994).

    Article  CAS  Google Scholar 

  2. Akhtar, S. & Juliano, R.L. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends cellBiol. 2, 139–144 (1992).

    Article  CAS  Google Scholar 

  3. Elkins, D.A. & Rossi, J.J. Cellular Delivery of ribozymes in Delivery Strategies for Antisense Oligonucleotide Therapeutics (ed. Akhtar, S.) (CRC Press, Boca Raton, Florida, USA, 1995).

    Google Scholar 

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Akhtar, S., James, H. & Gibson, I. Molecular DIY with hairpins and hammerheads. Nat Med 1, 300–302 (1995).

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