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Derailing heterotopic ossification and RARing to go

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Retinoic acid receptors inhibit chondrogenesis, but their ability to block the cartilaginous scaffold of heterotopic endochondral ossification has not been explored. A study in mice shows that agonists of retinoic acid receptor-γ potently inhibit heterotopic endochondral ossification, suggesting therapeutic potential in people with this condition (pages 454–460).

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Figure 1: RAR-γ agonists inhibit the cartilaginous scaffold of HEO.

Marina Corral

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Authors and Affiliations

  1. Frederick S. Kaplan is at the Departments of Orthopedic Surgery and Medicine and the Center for Research in FOR and Related Disorders, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

    Frederick S Kaplan

  2. Eileen M. Shore is at the Departments of Orthopedic Surgery and Genetics and the Center for Research in FOP and Related Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.,

    Eileen M Shore

Authors
  1. Frederick S Kaplan
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  2. Eileen M Shore
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Correspondence to Frederick S Kaplan.

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The authors declare no competing financial interests.

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Kaplan, F., Shore, E. Derailing heterotopic ossification and RARing to go. Nat Med 17, 420–421 (2011). https://doi.org/10.1038/nm0411-420

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