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Obesity: stressing about unfolded proteins

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A Corrigendum to this article was published on 01 May 2010

This article has been updated

Two reports in this issue identify a link between insulin action and the unfolded protein response—a pathway that helps the endoplasmic reticulum cope with cellular stress (pages 429–437 and 438–445). The results expand our understanding of the pathogenesis of insulin resistance and provide new targets for prevention and treatment of obesity.

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Figure 1: A link between insulin signaling and a stress response pathway of the endoplasmic reticulum.

Change history

  • 06 May 2010

    In the version of this News and Views initially published, the last name of one of the authors whose work was being discussed, Jonathon N. Winnay, was incorrectly spelled as ‘Winney’. The error has been corrected in the HTML and PDF versions of the article.

References

  1. Hotamisligil, G.S. Nature 444, 860–867 (2006).

    Article  CAS  Google Scholar 

  2. Park, S.W. et al. Nat. Med. 16, 429–437 (2010).

    Article  CAS  Google Scholar 

  3. Winnay, J.N., Boucher, J., Mori, M., Ueki, K. & Kahn, C.R. Nat. Med. 16, 438–445 (2010).

    Article  CAS  Google Scholar 

  4. van Herpen, N.A. & Schrauwen-Hinderling, V.B. Physiol. Behav. 94, 231–241 (2008).

    Article  CAS  Google Scholar 

  5. Eizirik, D.L., Cardozo, A.K. & Cnop, M. Endocr. Rev. 29, 42–61 (2008).

    Article  CAS  Google Scholar 

  6. Marciniak, S.J. & Ron, D. Physiol. Rev. 86, 1133–1149 (2006).

    Article  CAS  Google Scholar 

  7. Ozcan, U. et al. Science 306, 457–461 (2004).

    Article  Google Scholar 

  8. Wek, R.C. & Cavener, D.R. Antioxid. Redox Signal. 9, 2357–2371 (2007).

    Article  CAS  Google Scholar 

  9. Engelman, J.A., Luo, J. & Cantley, L.C. Nat. Rev. Genet. 7, 606–619 (2006).

    Article  CAS  Google Scholar 

  10. Taniguchi, C.M., Emanuelli, B. & Kahn, C.R. Nat. Rev. Mol. Cell Biol. 7, 85–96 (2006).

    Article  CAS  Google Scholar 

  11. Ozcan, U. et al. Science 313, 1137–1140 (2006).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Ronald C. Wek is in the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.,

    Ronald C Wek

  2. Tracy G. Anthony is in the Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, Indiana, USA.,

    Tracy G Anthony

Authors
  1. Ronald C Wek
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  2. Tracy G Anthony
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Correspondence to Ronald C Wek.

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The authors declare no competing financial interests.

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Wek, R., Anthony, T. Obesity: stressing about unfolded proteins. Nat Med 16, 374–376 (2010). https://doi.org/10.1038/nm0410-374

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