Skip to main content
Log in

Premature poking: impulsivity, cocaine and dopamine

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

'Impulsivity' occurs frequently in people with addiction and other common disorders such as attention deficit hyperactivity disorder (ADHD). Experiments in rats suggest that reduced dopamine receptor availability in the brain's ventral striatum may underlie links between impulsivity and addiction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Impulsivity model.

Ann Thomson

References

  1. Dalley, J.W. et al. Science 315, 1267–1270 (2007).

    Article  CAS  Google Scholar 

  2. Regier, D.A. et al. J. Am. Med. Assoc. 264, 2511–2518 (1990).

    Article  CAS  Google Scholar 

  3. Uhl, G.R. NeuroRx 3, 295–301 (2006).

    Article  Google Scholar 

  4. Volkow, N.D. et al. Synapse 46, 79–82 (2002).

    Article  CAS  Google Scholar 

  5. Smith, S.S. et al. Arch. Gen. Psychiatry 49, 723–727 (1992).

    Article  CAS  Google Scholar 

  6. Xu, K. et al. Arch. Gen. Psychiatry 61, 597–606 (2004).

    Article  CAS  Google Scholar 

  7. Gelernter, J. et al. Hum. Mol. Genet. 15, 3498–3507 (2006).

    Article  CAS  Google Scholar 

  8. Winstanley, C.A., Eagle, D.M. & Robbins, T.W. Clin. Psychol. Rev. 26, 379–395 (2006).

    Article  Google Scholar 

  9. Robbins, T.W. Psychopharmacology (Berl.) 163, 362–380 (2002).

    Article  CAS  Google Scholar 

  10. Reynolds, B. Behav. Pharmacol. 17, 651–667 (2006).

    Article  Google Scholar 

  11. Hyman, S.E., Malenka, R.C. & Nestler, E.J. Annu. Rev. Neurosci. 29, 565–598 (2006).

    Article  CAS  Google Scholar 

  12. Clark, L., Robbins, T.W., Ersche, K.D. & Sahakian, B.J. Biol. Psychiatry 60, 515–522 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uhl, G. Premature poking: impulsivity, cocaine and dopamine. Nat Med 13, 413–414 (2007). https://doi.org/10.1038/nm0407-413

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0407-413

  • Springer Nature America, Inc.

This article is cited by

Navigation